Drew Barrymore

Chloe (voice)

Piper Perabo

Rachel Ashe Lynn

Andy García

Delgado (voice)

George López

Papi (voice)

Paul Rodríguez

Chico (voice)

Plácido Domingo

Monte (voice)

Edward James Olmos

Diablo (voice)

Loretta Devine

Delta (voice)

Jamie Lee Curtis

Aunt Viv

Luis Guzmán

Chucho (voice)

Eddie 'Piolin' Sotelo

Rafa (voice)

Carlos Juvera

Tomás (voice)

Grey DeLisle

Mother Dog (voice)

Manolo Cardona

Sam Cortez

Leslie Mann

Bimini (uncredited)

Cheech Marin

Manuel (voice)

Michael Urie

Sebastian (voice)

José María Yázpik

Vasquez

Maury Sterling

Rafferty

Jesús Ochoa

Officer Ramirez

Eugenio Derbez

Store Owner

Omar Leyva

Ranger

Naomy Romo

Ranger

Ali Hillis

Angela

Marguerite Moreau

Blair

Nick Zano

Bryan

Gina Gallego

Shelter Director

Alberto Reyes

Bellman

Brandon Keener

Waiter

Sal Lopez

Ring Announcer

Giovanna Acha Aleman

Museum Guide

Jack Plotnick

Dog Nanny

Randall England

Butler

James P. Bennett

Bull Fighter (uncredited)

Mary Paz Mata

Shaman Lady

Tomihuatzi Xelhuantzi

Museum Security Guard

Mayra Sérbulo

Poor Woman

Fernando Manzano

Desk Sergeant