Milla Jovovich

Alice

Oded Fehr

Carlos Olivera

Ali Larter

Claire Redfield

Iain Glen

Dr. Isaacs

Ashanti

Betty

Christopher Egan

Mikey

Spencer Locke

K-Mart

Matthew Marsden

Slater

Linden Ashby

Chaser

Jason O'Mara

Albert Wesker

Mike Epps

L.J.

Joe Hursley

Otto

James Tumminia

Lab Tech

Madeline Carroll

White Queen

Valorie Hubbard

Ma

Carrie Eklund

Camp Survivor (uncredited)

Brian Steele

Rancid / Tyrant

John Eric Bentley

Umbrella Tech

Kirk B.R. Woller

Scientist

Rick Cramer

Ice Hockey / Corridor Guard

Peter O'Meara

British Envoy

William Abadie

French Envoy

Ramón Franco

Runty

Shane Woodson

Piggy

Geoff Meed

Pock Mark

Rusty Joiner

Eddie

Connor McCoy

Small Boy

Carolina Jiménez

Mirror Woman

Gary A. Hecker

Tyrant Vocal (voice)

Martin Crewes

Chad Kaplan (uncredited)

Richard Epcar

Additional Voices (voice) (uncredited)

Stefen Hayes

Yuri Loginova (uncredited)

Gary Hudson

Umbrella Captain (uncredited)

Ryan McCluskey

Mr. Grey (uncredited)

Carsten Nørgaard

Zombie Steve (uncredited)

César Ámigo Aguilar

Foreign Envoy (uncredited)